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. 2022 Sep 2;12:978533. doi: 10.3389/fonc.2022.978533

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Copyright © 2022 Wu, Huo, Yang, Liu, Wu, Feng, Wang, Li, Jia, Zhang, Gao and Yu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Synthesis and properties of CRISPR/Cas9_-3NLS/sgHMGA2@PDA (A) The schematic synthesis of the CRISPR/Cas9_-3NLS/sgHMGA2@PDA delivery system. (B, C) The TEM of CRISPR/Cas9_-3NLS/sgHMGA2@PDA. (D) Zeta potentials of CRISPR/Cas9_-3NLS/sgHMGA2 and CRISPR/Cas9-_3NLS/sgHMGA2@PDA in water. (E) CRISPR/Cas9_-3NLS-AF-488/sgHMGA2 release profiles of CRISPR/Cas9_-3NLS/sgHMGA2@PDA in different pH environments. ****P < 0.001, Student’s t test. Error bars represent SD.