Table 1.
Clinical characteristics of 651 patients with primary glioma in the CGGA dataset according to CASP6 expression.
| CASP6 expression level | High | Low | P-value | |
|---|---|---|---|---|
| Number | 325 | 326 | ||
| CASP6_mRNA (median[IQR]) | 3.13 [2.79, 3.51] | 1.81 [1.22, 2.12] | <0.001 | |
| Age (%) | ≤42 | 133 (40.9) | 181 (55.5) | <0.001 |
| >42 | 191 (58.8) | 145 (44.5) | ||
| Gender (%) | Female | 130 (40.0) | 136 (41.7) | 0.714 |
| Male | 195 (59.7) | 190 (58.3) | ||
| Grade (%) | II | 70 (21.5) | 162 (49.7) | <0.001 |
| III | 87 (26.8) | 107 (32.8) | ||
| IV | 168 (51.7) | 57 (17.5) | ||
| Histology (%) | A (Astrocytoma) | 57 (17.5) | 74 (22.7) | <0.001 |
| AA (Anaplastic Astrocytoma) | 73 (22.5) | 47 (14.4) | ||
| AO (Anaplastic Oligodendroglioma) | 14 (4.3) | 44 (13.5) | ||
| AOA (Anaplastic Oligoastrocytoma) | 0 (0.0) | 16 (4.9) | ||
| GBM | 168 (51.7) | 57 (17.5) | ||
| O (Oligodendroglioma) | 11 (3.4) | 82 (25.2) | ||
| OA (Oligoastrocytoma) | 2 (0.6) | 6 (1.8) | ||
| Survival (median[IQR]) | 22.7 [11.9, 51.8] | 66.1 [30.2, 93.7] | <0.001 | |
| Status (%) | Alive | 73 (22.5) | 208 (63.8) | <0.001 |
| Dead | 244 (75.1) | 105 (32.2) | ||
| IDH status (%) | Wildtype | 215 (66.2) | 72 (22.1) | <0.001 |
| Mutant | 107 (32.9) | 217 (66.6) | ||
| 1p19q (%) | Non-codel | 302 (92.9) | 144 (44.2) | <0.001 |
| Codel | 22 (6.8) | 120 (36.8) | ||
| MGMTp methylation status (%) | un-methylated | 148 (45.5) | 114 (35.0) | 0.037 |
| methylated | 140 (43.1) | 156 (47.9) | ||
| Radio status (%) | No | 43 (13.2) | 71 (21.8) | 0.006 |
| Yes | 266 (81.8) | 240 (73.6) | ||
| Chemo status (%) | No | 88 (27.1) | 113 (34.7) | 0.036 |
| Yes | 217 (66.8) | 191 (58.6) |