Table 2.
Univariate and multivariate analysis of CASP6 and clinical features in the CGGA datasets.
| Univariate Cox analysis of CGGA (n=1018) | Multivariate Cox analysis CGGA (n=1018) | ||||
|---|---|---|---|---|---|
| Variables | p value | HR (95%CI) | Variables | p value | HR (95%CI) |
| CASP6 | 7.52E-30 | 2.1 (1.85-2.38) | CASP6 | 1.70E-06 | 1.64 (1.34-2.01) |
| Age | 2.53E-21 | 1.04 (1.04-1.05) | Age | 4.83E-05 | 1.02 (1.01-1.03) |
| Gender (Male vs. Female) |
0.565 | 1.07 (0.86-1.32) | Gender (Male vs. Female) |
0.861 | 0.98 (0.76-1.26) |
| Grade (WHOIV vs. WHOIII vs. WHOII) |
2.65E-48 | 2.99 (2.58-3.46) | Grade (WHOIV vs. WHOIII vs. WHOII) |
4.83E-09 | 1.89 (1.53-2.34) |
| Radio-status (Treated vs. Untreated) |
0.0429 | 1.38 (1.01-1.88) | Radio-status (Treated vs. Untreated) |
0.447 | 0.87 (0.6-1.26) |
| Chemo-status (Treated vs. Untreated) |
0.0286 | 1.3 (1.03-1.65) | Chemo-status (Treated vs. Untreated) |
0.00106 | 0.61 (0.46-0.82) |
| IDH (Mutant vs. Wildtype) |
1.78E-37 | 0.22 (0.18-0.28) | IDH (Mutant vs. Wildtype) |
0.127 | 0.77 (0.54-1.08) |
| 1p19q (Codeletion vs. non-Codeletionl) |
1.44E-19 | 0.14 (0.09-0.21) | 1p19q (Codeletion vs. non-Codeletionl) |
7.25E-05 | 0.35 (0.21-0.59) |
| MGMT (methyltransferase vs. non- methyltransferase |
0.000936 | 0.68 (0.55-0.86) | MGMT (methyltransferase vs. non- methyltransferase |
0.0353 | 0.76 (0.59-0.98) |
HR, hazard ratio; IDH, isocitrate dehydrogenases; MGMT, O-6-methylguanine-DNA methyltransferase.