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. Author manuscript; available in PMC: 2023 Aug 1.
Published in final edited form as: J Am Acad Child Adolesc Psychiatry. 2022 Jan 25;61(8):1023–1033. doi: 10.1016/j.jaac.2021.12.015

Figure 2. Connectivity Changes From Baseline to Week 1 and Week 6 During Drug Treatment.

Figure 2.

(A) one-week changes of L VLPFC-L temporal pole connectivity and L OFC-R postcentral gyrus connectivity in the quetiapine, lithium, and healthy group. The quetiapine group showed significant normalization relative to the control group while the lithium group did not show this effect. (B) Six-week changes from baseline of L insula-ACC and right amygdala and right occipital pole connectivity in patients and healthy individuals. Patients with BD showed significant normalization relative to the control group in connectivity between L insula and ACC and between R AMY to R Occipital pole. (C) Six-week changes (three points in time) of L insula-ACC connectivity in patients and healthy individuals. Patients with BD showed significant normalization relative to the control group in connectivity between L insula and ACC. ACC = anterior cingulate cortex; HC = healthy controls; L = left; Li = lithium; OFC = orbital frontal cortex; Que = quetiapine; R = right; WK = week; VLPFC = ventrolateral prefrontal cortex.