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. 2022 Sep 2;13:942768. doi: 10.3389/fimmu.2022.942768

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Copyright © 2022 Lv, Ying, Hu, Hu, Jian and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lipidomics reveals microglia activation with triacylglycerol (TAG) accumulation. (A) The volcano plot shows the comparison of cell lipids between control and hypoxia. The blue and red dots indicate lipids downregulated and upregulated under hypoxia compared with control, respectively (fold change > 1.2, p < 0.05). (B) Heatmap representation of differentially abundance lipids. (C) Analysis of differential lipid pathway induced by hypoxia stress using BioPAN. (D) Lipid species most activated and suppressed in the hypoxia group compared with control. (E) Heatmap representation of diacylglycerol (DAG) -16:0/18:2, phosphatidylethanolamine (PE) -16:0/18:2, and phosphatidylcholines (PC) -16:0/18:2 +AcO (ant colony optimization) in the hypoxia and control groups. (F) Counts-per-million (CMP) values of Pemt and Cept1 expression in the control and hypoxia groups. *p < 0.05.