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. 2022 Sep 16;19:228. doi: 10.1186/s12974-022-02592-x

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — IL-6 blockade prevents vasospasm and improves neurologic scores. Schematic of SAH model set-up (A). Vasospasm measurements with arrows showing areas of vasospasm (B). A significant decrease in MCA/ICA ratio seen after SAH (p < 0.001). This was mitigated by IL-6 blockade (p < 0.01) (C). Mice with SAH had worse modified Garcia scale scores (p < 0.001), but improvement was seen with IL-6 blockade (p < 0.01) (D). Percentage of right turns (indicating impaired left motor functioning) was seen on post-SAH day 1 (p < 0.001) with improvement with IL-6 blockade (p < 0.01) (E). This effect was maintained on post-SAH day 3 (p < 0.01) with continued IL-6 blockade benefit (p < 0.05) (F). By post-SAH 5, the SAH mice were returning towards baseline but still had significant difference (p < 0.05) with benefit from IL-6 blockade (p < 0.05) (G). Black scale bar = 100 μm. * = comparison to saline, # = comparison to SAH