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. 2022 Sep 16;41:275. doi: 10.1186/s13046-022-02475-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — ETV1 is vital for HGF-mediated HCC invasion and metastasis. (A) The protein levels of ETV1 in the PLC/PRF/5 cells transfected with LV-sh Control or LV-shETV1 upon HGF treatment. (B) Transwell assays displayed the migratory and invasive capacity of the indicated cells upon HGF treatment. (C) The levels of HGF and ETV1 in the PLC/PRF/5-HGF cells transfected with LV-shControl or LV-shETV1. (D) Transwell assays displayed the migratory and invasive capacity of the indicated cells. (E-J) In vivo metastatic assay. (E) The representative BLI images in the liver were shown 9 weeks after implantation with indicated cells. (F) The bioluminescent signals were used to show the growth rate of liver tumors. (G) The number of metastatic lesions in the lung tissues. (H) The occurrence of lung metastasis. (I) The OS of different groups of nude mice. (J) Representative images of H&E staining of lung samples (indicated by arrowheads) from each group. * Represented p < 0.05. All data were displayed as Mean ± SD