Table 1. Comparing technology platforms.

Each broad class of single-cell technology offers advantages and disadvantages in terms of throughput and cost, flexibility to be adapted to different modalities (RNA, ATAC, DNA methylation, etc.), sensitivity, protocol simplicity (often owing to robust commercialized kits), and widespread adoption rate, which expands the existing knowledgebase about the platform and allows for easy comparison with other similar datasets.

	Throughput (cost/labor per cell)	Flexibility	Sensitivity / Max Depth	Protocol Simplicity / Accessibility	Adoption / Available public datasets
Droplet	++	+	++	+++	+++
Sorted/Plate-based	+	+++	+++	++	++
Microwell	++	++	++	+	+
Split / Pool	+++	++	++	++	++