Fig. 13.

Neutrophil-based delivery systems for overcoming the BBB and penetration into the brain tumor: A Schematic illustration of the preparation of neutrophils modified with paclitaxel-loaded liposomes to target glioma tumors in mice. Below, in vivo fluorescence imaging of the normal and glioma-bearing mice after intravenous administration of neutrophils-based vehicles is shown. Adapted with permission from Ref. [377]. B TEM images of the neutrophil-exosomes system for the delivery of the antitumor drug DOX into the glioma (scale bar = 100 nm). Below, in vivo results (6-Luc glioma-bearing mice model) demonstrate that this cell-based vehicle can transport the drug through the BBB and migrate into the brain tumor with high efficiency. Adapted with permission from Ref. [382]