TABLE 1.
Examples of redundancy within the C. elegans proliferation versus differentiation decision.
| Type of redundancy | Description | Germline Example |
|---|---|---|
| Molecular | Effectors function through identical mechanisms to regulate the exact target | PUF-3 ↔ PUF-11a |
| LST-1 ↔ SYGL-1b | ||
| Target | Effectors modulate the same target but through unique mechanisms | FBF-1 ↔ FBF-2 |
| PUF-3 ↔ PUF-11a | ||
| FBF-1 ↔ FBF-2 ↔ PUF-3 ↔ PUF-11c | ||
| LST-1 ↔ SYGL-1b | ||
| Pathway | Effectors regulate different targets within the same overall pathway | FBF-1 ↔ FBF-2 ↔ PUF-3 ↔ PUF-11c |
| Cellular | Effectors regulate complementary pathways which control the same cellular outcome | GLD-1 ↔ GLD-2 ↔ SCFPROM−1 |
| Splicing factors ↔ GLD-2 | ||
| Protein degradation ↔ GLD-2 |
a
Based on the current data PUF-3 and PUF-11 could utilize different types of redundancy. See section 4.2 for full explanation.
b
Based on the current data LST-1 and SYGL-1 could utilize different types of redundancy. See section 4.3 for full explanation
c
Based on the Current data the PUF hub components (FBF-1, FBF-2, PUF-11, PUF-3) could utilize different types of redundancy. See section 4.2 for full explanation.