TABLE 1.

Comparison of small molecule inhibitors, monoclonal antibodies, nucleic acid based therapies and PROTACs as potential antitumor therapies.

	Small molecule inhibitors	Monoclonal antibodies	Nucleic acid based therapies	PROTACs
Target	Intracellular and cell surface proteins	Cell surface proteins only	DNA or RNA	Intracellular and cell surface proteins
Tissue Penetration	Broad	Limited	Limited	Broad
Oral bioavailability	Easily achievable	Not achievable	Not achievable	Achievable
Target Undruggable Proteins	No	Only membrane proteins	Not applicable	Yes
Target Scaffolding Proteins	No	Not Applicable	Not Applicable	Yes
Drug resistance due to mutations	Yes	Yes	Not applicable	No
Possibility for high drug potency	Poor	Yes	Yes	Yes
Mode of action catalytic	No	No	Yes	Yes