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. 2022 Sep 2;16:982881. doi: 10.3389/fncel.2022.982881

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Closed-loop rehabilitation modes: large closed-loop rehabilitation mode, small closed-loop rehabilitation mode, and tiny closed-loop rehabilitation mode (The written informed consent was obtained from the individual for the publication of the image). Red arrow: tiny closed-loop rehabilitation mode, the modulation effect in the intra-hemisphere or the inter-hemisphere. Blue arrow: small closed-loop rehabilitation mode, an intervention strategy that relies on independent, comprehensive intervention that does not combine with peripheral interventions. Yellow arrow: large closed-loop rehabilitation mode, the different combinations of central intervention techniques combined with peripheral intervention technique.