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. 2022 Sep 2;13:937741. doi: 10.3389/fphar.2022.937741

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Copyright © 2022 Johnson, Doucette, Edwards, Verdi, McFarland, Hulke, Fowler, Watts and Klein.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Animal mobility, thermal sensitivity and open field behaviors are not affected in mice with intrathecal knockdown of Adcy1. Mice underwent behavioral assessments to gauge mobility and the presence of behavioral deficits after intrathecal injection of AAV9-GFP-U6-m-Adcy1-shRNA (●) or AAV9-GFP-U6-scramble-shRNA (□) intrathecal injections. The (A) maximum time spent on a rotating rod, (B) thermal paw withdrawal latency, open field assessments including the (C) distance traveled, (D) velocity, and (E) total change in angular orientation were not significantly different between treatment groups. (F) The time spent immobile in seconds was significantly decreased in AAV9-Adcy1 compared to AAV9-scramble mice (unpaired t-test, p = 0.0433), n = 10/group.