Table 3.

Summaries of the quality of evidence of included studies.

References	Study design	Study group sizes	Subject enrolment quality	Overall risk of bias
Wu et al. (2021)	bRELAS	Moderate	Fairly	Low/Moderate
Zhao et al. (2021)	bRELAS	Small	Fairly	Moderate
Wang et al. (2020)	nRELAS	Good	Unclear	Moderate
Zhang et al. (2020)	bRELAS	Moderate	Fairly	Low/Moderate
Guo et al. (2019)	nbRELAS	Moderate	Unclear	Moderate/High
Afshari et al. (2018)	nRELAS	Moderate	Unclear	Low/Moderate
Guo et al. (2018)	bRELAS	Small	Unclear	Moderate
Wang et al. (2018)	nRELAS	Small	Unclear	Moderate
Zhang et al. (2017a)	nRELAS	Small	Unclear	Low/Moderate
Zhang et al. (2017b)	nRELAS	Small	Unclear	Low/Moderate
Wang et al. (2016)	bRELAS	Moderate	Unclear	Moderate
Lin et al. (2015)	nRELAS	Moderate	Unclear	Low/Moderate

bRELAS, blinded randomized experimental laboratory animal studies; nbRELAS, non-blinded randomized experimental laboratory animal studies; nRELAS, non-randomized experimental laboratory animal studies.