Table 2.
Transamination of different ketones using ATA@NITQ-2 as the biocatalyst.
| Entry | Reactive | Product | Time (h) | Yield (%)/ee(%) |
|---|---|---|---|---|
| 1 | 112 | (S) 96/99(R) 95/99 | ||
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| 2 | 1 | (S) 98/99 | ||
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| 3 | 1 | (S) 86/99 | ||
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| 4 | 2 | (S) 80/99 | ||
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| 5 | 2 | (S) 86/99 | ||
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| 6 | 2 | (S) 84/99 | ||
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| 7 | 2 | (S) 88/99 | ||
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| 8 | 24 | (S) 90/99 | ||
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Reaction conditions: ATA@NITQ-2 (104 mg), ketone (15 mM), the cofactor (PLP) (1 mM) in 2 mL of solvent (isopropylamine (pH 7, 2 M)/phosphate buffer solution, pH 7, 100 mM) (50/50, v/v) and DMSO (10%) as co-solvent, at 37°C while stirring at 1400 r/min.