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. 2022 Oct;28(10):1281–1297. doi: 10.1261/rna.079266.122

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© 2022 Hajji et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article, published in RNA, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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FIGURE 2. — The domain structure of major ADAR2 protein isoforms. Human ADAR2 has two major isoforms: ADAR2a (ADAR2S) and ADAR2b (ADAR2L). Both isoforms have two amino-terminal dsRBDs (pink) and a carboxy-terminal deaminase domain (light yellow), as well as an NLS (lilac) at the amino terminus. The longer isoform ADAR2b (ADAR2L) has an extra Alu-derived insert (light blue) in the deaminase domain. ADAR2 has further isoforms differing at the carboxyl terminus, with either a long (blue) or short (yellow; C-ter. S) terminus that is generated by alternative splicing. The adult Drosophila ADAR is the ortholog of mammalian ADAR2, with a slightly shorter deaminase domain.