Figure 1:

Treatment of oxidized low-density lipoprotein upregulated the level of circular (circ)_0002194 in human umbilical vein endothelial cells (HUVECs). (A) The circ_0002194 level was examined using reverse transcription-quantitative polymerase chain reaction after the HUVECs were treated with 0 μg/ml, 25 μg/ml, 50 μg/ml or 100 μg/ml oxidized low-density lipoprotein. (B) The genic information of circ_0002194. (C-D) The levels of circ_0002194 and RELT-like 1 were quantified by the reverse transcription-quantitative polymerase chain reaction after RNA was treated with RNase R (C) or HUVECs were incubated with actinomycin D (D). *P < 0.05. circ: circular; RELL1: RELT-like 1.