Table 1.

The reported pathways and molecular targets regulated by BBR in different BC cell lines.

Dosage	Function	Type of cell lines	Study model	References
1, 2, and 4 mg/kg	BBR act directly on the poly(A) tail	The male mice	In vitro	(124)
MDA-MB-231: 0, 6.25, 12.5, and 25 µM; MDA-MB-468: 0, 3, 6, and 12 µM; MDA-MB-453: 0, 2.5, 5, and 10 µM	Induce cell cycle arrestReduce the expression of cyclin D and Cyclin E	MDA-MB-231, MDA-MB-468, MDA-MB-453, and BT-549 cells	In vitro	(125)
100 mM	Suppress the expressions of MMP-1 and MMP-9	MCF-7 and MDA-MB231	In vitro	(99)
BBR: 0–40 µMEMO: 0–40 µM	BBR binds with SIK3 to inhibit SIK3 activityInduce cell cycle arrest at G1/S cell cycle arrest and apoptosis	MCF-7, T47D, MDA-MB-468, and MDA-MB-231 cells	In vitro	(35)
5, 10, and 20 μmol/L	Inhibit the AMPK pathway to induces cell death and apoptosis	MCF-7/MDR cells	In vitro	(88)
25 and 50 µM	Upregulate miR-214-3pReduce SCT	MCF-7 and MDAMB-231 cells	In vitro	(63)
0–16μg/ml	Reduce nuclear CDK4Downregulate Wnt/β	MCF-7 cells	In vitro	(68)