Additional Table 1.

Univariate analysis of possible outcome predictors for treatment effects at four time points in PRF + ozone group

Predictor	Pre-treatment					3 mon					6 mon					1 yr
	Effective	Ineffective	OR	95% CI	P-value	Effective	Ineffective	OR	95% CI	P-value	Effective	Ineffetive	OR	95% CI	P-value	Effective	Ineffective	OR	95% CI	P-value
Age (yr)			0.2	0.0	0.4			1.5	0.4	0.4			1.5	0.3	0.5			1.2	0.2	0.7
<65	3	14	31	54-	10	10	7	38	52-	90	13	4	00	41-	90	10	4	50	36-	93
≥65	13	14		0.9		13	14		5.2		13	6		6.5		8	4		6.6
				91					42					92					33
Gender			1.3	0.3	0.6			1.2	0.3	0.7			1.3	0.3	0.6			1.6	0.3	0.5
Male	8	12	33	89-	47	11	9	22	72-	41	12	4	33	89-	47	9	3	67	03-	55
Female	8	16		4.5		12	12		4.0		14	6		4.5		9	5		9.1
				76					18					76					57
Disease			1.0	0.3	0.9			1.4	0.4	0.5			0.4	0.1	0.3			0.8	0.1	0.7
course			37	00-	54			90	48-	15			89	11-	41			00	51-	93
(yr)				3.5					4.9					2.1					4.2
< 1	7	12		81		11	8		56		11	6		59		8	4		45
≥1
	9	16				12	13				15	4				10	4
Diabete			0.3	0.0	0.1			1.1	0.2	0.8			0.9	0.0	0.3			0.1	0.2	0.0
s			02	56-	48			29	87-	62			60	95-	10			71	80-	46*
With	2	9		1.6		6	5		4.4		6	4		2.1		4	5		1.0
Without	14	19		19		17	16		41		20	6		41		14	3		50
Hyperte			0.9	0.2	0.9			0.8	0.2	0.8			0.7	0.1	0.7			0.3	0.0	0.1
nsion			60	56-	51			75	46-	37			94	77-	63			00	53-	65
With	5	9		3.5		7	7		3.1		9	4		3.5		6	5		1.7
Without	11	19		98		16	14		15		17	6		63		12	3		00
Treatm			1.3	0.3	0.6			0.8	0.2	0.7			2.3	0.4	0.2			0.3	0.0	0.2
ent			33	89-	47			46	58-	83			33	92-	79			85	68-	72
number				4.5					2.7					11.					2.1
< 10	8	12		76		10	10		78		13	3		056		5	4		64
≥10	8	16				13	11				13	7				13	4

Note: CI: Confidence interval; OR: odd ratio.