Table 2.
Study/Trial name | Treatment /Control group | PFS of 18 months since first dose of Daratumumab | ORR* | VGPR* | CR* | PR* | MR* |
---|---|---|---|---|---|---|---|
Dimopoulo s et al./CANDOR Trial | Treatment group | 57 (18.3%) | 263 (84.3%) | 216 (69%) | 89 (28.5%) | 55 (17.6%) | 23 (7.4%) |
Control group | 13 (8%) | 115 (74.6%) | 75 (49%) | 16 (10.4%) | 6 (4%) | 22 (14.3%) | |
Spencer, et al./CASTOR trial | Treatment group | 188 (74%) | 201 (80.1%) | 149 (59.3%) | 69 (27.4%) | 52 (20.7%) | 9 (3.6%) |
Control group | 24 (9.7%) | 148 (59.9%) | 68 (27.5%) | 23 (9.3%) | 80 (32.4%) | 20 (8.1%) | |
Dimopoulo s, et al./POLLUX Trial | Treatment group | 203 (71%) | 261 (91.2%) | 221 (77.2%) | 144 (50.3%) | 40 (14%) | 5 (1.7%) |
Control group | 127 (45%) | 211 (74.5%) | 132 (46.6%) | 58 (20.5%) | 79 (28%) | 26 (9.2%) |
*PFS: Progression free span, ORR=overall response rate, VGPR=Very good partial response, CR=Complete response, PR=Partial response, MR=Minimal Response