Table 1. Summary of protein-based nanoparticles and virus like particles tested in this study.

Protein based nanoparticles
	Organism	MW (KDa)	PDB code	N° Subunit	MW NP (KDa)	Diameter (nm)	Phase study
Ferritin	H. pylori	15	3BVE	24	360	10	Clinical
mI3	*Computationally designed from T. maritima aldolase	25	5KP9	60	1500	18	Preclinical
Encapsulin	T. maritima	32	3DKT	60	1920	24	Preclinical
Virus-like particles
CP3	AP205 bacteriophage	15	5LQP	180	2700	30	Preclinical
Qβ	Qβ bacteriophage	16	1QBE	180	2880	30	Clinical
HBcAg	Human hepatitis B virus	16	1QGT	240	3840	34	Clinical

*mI3 derives from the optimization of the I03 nanoparticle previously designed by Hsia et al. [35, 36]. The structures of mI3 and I03 have not been reported, consequently for the structural analysis a closely related icosahedral T. maritima particle (see PDB 5KP9) was used as a reference.