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. 2022 Sep 16;17(9):e0274880. doi: 10.1371/journal.pone.0274880

Table 1. Genotype distribution in professional athletes, elite endurance athletes, professional football players and non-athletes of liver metabolism polymorphisms.

Symbol Gene Polymorphism dbSNP Genotype Score Professional athletes Elite endurance athletes Professional football players Elite Endurance athletes vs. Professional football players p-value non-athletes Professional athletes vs. non-athletes p-value Elite endurance athletes vs. non-athletes p-value Professional football players vs. non-athletes p-value
CYP2D6 cytochrome P450 family 2 subfamily D member 6 c.506-1G>A rs3892097 2 = GG 272 (93.2%) 142 (88.8%) 130 (98.5%) 0.002 98 (61.1%) < 0.001 < 0.001 <0.001
1 = GA 18 (6.2%) 17 (10.6%) 1 (0.8%) 59 (37.0%)
0 = AA 2 (0.7%) 1 (0.6%) 1 (0.8%) 3 (1.9%)
GSTM1 glutathione-S transferase mu isoform 1 "Null" polymorphism 1 = + 121 (41.4%) 59 (36.9%) 62 (47.0%) 0.081 57 (35.7%) 0.389 0.999 0.104
0 = - 171 (58.6%) 101 (63.1%) 70 (53.0%) 103 (64.3%)
GSTP glutathione S-transferase pi c.313A>G rs1695 2 = AA 147 (50.3%) 91 (56.9%) 56 (42.4%) 0.014 80 (50.0%) 0.975 0.306 0.423
1 = GA 116 (39.7%) 59 (36.9%) 57 (43.2%) 64 (39.9%)
0 = GG 29 (10.0%) 10 (6.3%) 19 (14.4%) 16 (10.1%)
GSTT glutathione S-transferase theta +/- 2 = +/+ 123 (42.1%) 72 (45.0%) 51 (38.6%) <0.001 64 (40.0%) 0.205 0.779 0.003
1 = +/- 89 (30.5%) 34 (21.3%) 55 (41.7%) 39 (24.4%)
0 = -/- 80 (27.4%) 54 (33.8%) 26 (19.7%) 57 (35.6%)