Table 1. Genotype distribution in professional athletes, elite endurance athletes, professional football players and non-athletes of liver metabolism polymorphisms.
Symbol | Gene | Polymorphism | dbSNP | Genotype Score | Professional athletes | Elite endurance athletes | Professional football players | Elite Endurance athletes vs. Professional football players p-value | non-athletes | Professional athletes vs. non-athletes p-value | Elite endurance athletes vs. non-athletes p-value | Professional football players vs. non-athletes p-value |
---|---|---|---|---|---|---|---|---|---|---|---|---|
CYP2D6 | cytochrome P450 family 2 subfamily D member 6 | c.506-1G>A | rs3892097 | 2 = GG | 272 (93.2%) | 142 (88.8%) | 130 (98.5%) | 0.002 | 98 (61.1%) | < 0.001 | < 0.001 | <0.001 |
1 = GA | 18 (6.2%) | 17 (10.6%) | 1 (0.8%) | 59 (37.0%) | ||||||||
0 = AA | 2 (0.7%) | 1 (0.6%) | 1 (0.8%) | 3 (1.9%) | ||||||||
GSTM1 | glutathione-S transferase mu isoform 1 | "Null" polymorphism | 1 = + | 121 (41.4%) | 59 (36.9%) | 62 (47.0%) | 0.081 | 57 (35.7%) | 0.389 | 0.999 | 0.104 | |
0 = - | 171 (58.6%) | 101 (63.1%) | 70 (53.0%) | 103 (64.3%) | ||||||||
GSTP | glutathione S-transferase pi | c.313A>G | rs1695 | 2 = AA | 147 (50.3%) | 91 (56.9%) | 56 (42.4%) | 0.014 | 80 (50.0%) | 0.975 | 0.306 | 0.423 |
1 = GA | 116 (39.7%) | 59 (36.9%) | 57 (43.2%) | 64 (39.9%) | ||||||||
0 = GG | 29 (10.0%) | 10 (6.3%) | 19 (14.4%) | 16 (10.1%) | ||||||||
GSTT | glutathione S-transferase theta | +/- | 2 = +/+ | 123 (42.1%) | 72 (45.0%) | 51 (38.6%) | <0.001 | 64 (40.0%) | 0.205 | 0.779 | 0.003 | |
1 = +/- | 89 (30.5%) | 34 (21.3%) | 55 (41.7%) | 39 (24.4%) | ||||||||
0 = -/- | 80 (27.4%) | 54 (33.8%) | 26 (19.7%) | 57 (35.6%) |