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. 2022 Sep 16;17(9):e0274880. doi: 10.1371/journal.pone.0274880

Table 2. Genotype distribution in professional athletes, elite endurance athletes, professional football players and non-athletes of iron metabolism and energy efficiency polymorphisms.

Symbol Gene Polymorphism dbSNP Genotype Score Professional athletes Elite endurance athletes Professional football players Elite endurance athletes vs. Professional football players p-value non-athletes Professional athletes vs. non-athletes p-value Elite endurance athletes vs. non-athletes p-value Professional football players vs. non-athletes p-value
HFE Homeostatic Iron Regulator c.187C>G rs1799945 2 = GG 16 (5.8%) 8 (5.0%) 8 (6.1%) 0.001 0 (0.0%) 0.001 <0.001 0.013
1 = GC 115 (39.0%) 78 (48.8%) 37 (28.0%) 43 (26.8%)
0 = CC 161 (55.2%) 74 (46.2%) 87 (65.9%) 117 (73.2%)
HFE Homeostatic Iron Regulator c.845G>A rs1800562 2 = AA 1 (0.3%) 0 (0.0%) 1 (0.8%) 0.449 0 (0.0%) 0.621 0.998 0.404
1 = GA 16 (5.5%) 10 (6.3%) 6 (4.5%) 10 (6.3%)
0 = GG 275 (94.2%) 150 (93.7%) 125 (94.7%) 150 (93.7%)
AMPD1 Adenosine monophosphate deaminase 1 c.34C>T rs17602729 2 = CC 233 (79.8%) 128 (80.0%) 105 (79.6%) 0.291 99 (62.1%) 0.006 0.010 0.014
1 = CT 57 (19.5%) 32 (20.0%) 25 (18.9%) 60 (37.4%)
0 = TT 2 (0.7%) 0 (0.0%) 2 (1.5%) 1 (0.5%)
PGC1a Peroxisome proliferator activated receptor coactivator c.1444 G>A rs8192678 2 = GG 192 (65.7%) 105 (65.6%) 87 (65.9%) 0.347 88 (54.8%) 0.232 0.523 0.119
1 = GA 91 (31.1%) 53 (33.1%) 38 (28.8%) 63 (39.7%)
0 = AA 9 (3.2%) 2 (1.3%) 7 (5.3%) 9 (5.5%)