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. 2022 Sep 16;17(9):e0274880. doi: 10.1371/journal.pone.0274880

Table 4. Genotype distribution in professional athletes, elite endurance athletes, professional football players and non-athletes for muscle injuries polymorphisms.

Symbol Gene Polymorphism dbSNP Genotype Score Professional athletes Elite endurance athletes Professional football players Elite endurance athletes vs. Professional football players p-value non-athletes Professional athletes vs. non-athletes p-value Elite endurance athletes vs. non-athletes p-value Professional football players vs. non-athletes p-value
ACE Angiotensin I-converting enzyme Alu 287bp (I/D) rs4340 2 = DD 140 (47.9%) 79 (49.4%) 61 (46.2%) 0.175 62 (38.7%) 0.034 0.011 0.216
1 = ID 114 (39.0%) 56 (35.0%) 58 (43.9%) 82 (51.2%)
0 = II 38 (13.1%) 25 (15.6%) 13 (9.9%) 16 (10.1%)
ACTN3 α-actinin 3 c.1729C>T rs1815739 2 = CC 91 (31.2%) 55 (34.4%) 36 (27.3%) 0.211 48 (30.0%) 0.681 0.678 0.410
1 = TC 150 (51.4%) 82 (51.2%) 68 (51.5%) 91 (56.6%)
0 = TT 51 (17.4%) 23 (14.4%) 28 (21.2%) 21 (13.4%)
AMPD1 Adenosine Monophosphate Deaminase 1 c.34C>T rs17602729 2 = CC 233 (79.8%) 128 (80.0%) 105 (79.6%) 0.291 99 (62.1%) 0.006 0.010 0.014
1 = CT 57 (19.5%) 32 (20.0%) 25 (18.9%) 60 (37.4%)
0 = TT 2 (0.7%) 0 (0.0%) 2 (1.5%) 1 (0.5%)
CKM Muscle-specific creatine kinase c.*800A>G rs8111989 2 = GG 26 (8.9%) 16 (10.0%) 10 (7.6%) 0.418 10 (5.9%) 0.718 0.326 0.384
1 = GA 142 (48.6%) 88 (55.0%) 54 (40.9%) 72 (45.3%)
0 = AA 124 (42.5%) 56 (35.0%) 68 (51.5%) 78 (48.8%)
MLCK Myosin-light chain kinase c.37885C>A rs28497577 2 = AA 1 (0.4%) 0 (0.0%) 1 (0.8%) 0.002 1 (0.6%) <0.001 <0.001 <0.001
1 = CA 217 (74.3%) 107 (66.9%) 110 (83.3%) 56 (35.3%)
0 = CC 74 (25.3%) 53 (33.1%) 21 (15.9%) 103 (64.1%)
MLCK Myosin-light chain kinase c.49C>T rs2700352 2 = CC 167 (57.2%) 79 (49.4%) 88 (66.7%) 0.001 31 (19.6%) <0.001 <0.001 <0.001
1 = CT 99 (33.9%) 59 (36.8%) 40 (30.3%) 109 (68.1%)
0 = TT 26 (8.9%) 22 (13.8%) 4 (3.0%) 20 (12.3%)