Table 4. Genotype distribution in professional athletes, elite endurance athletes, professional football players and non-athletes for muscle injuries polymorphisms.
Symbol | Gene | Polymorphism | dbSNP | Genotype Score | Professional athletes | Elite endurance athletes | Professional football players | Elite endurance athletes vs. Professional football players p-value | non-athletes | Professional athletes vs. non-athletes p-value | Elite endurance athletes vs. non-athletes p-value | Professional football players vs. non-athletes p-value |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ACE | Angiotensin I-converting enzyme | Alu 287bp (I/D) | rs4340 | 2 = DD | 140 (47.9%) | 79 (49.4%) | 61 (46.2%) | 0.175 | 62 (38.7%) | 0.034 | 0.011 | 0.216 |
1 = ID | 114 (39.0%) | 56 (35.0%) | 58 (43.9%) | 82 (51.2%) | ||||||||
0 = II | 38 (13.1%) | 25 (15.6%) | 13 (9.9%) | 16 (10.1%) | ||||||||
ACTN3 | α-actinin 3 | c.1729C>T | rs1815739 | 2 = CC | 91 (31.2%) | 55 (34.4%) | 36 (27.3%) | 0.211 | 48 (30.0%) | 0.681 | 0.678 | 0.410 |
1 = TC | 150 (51.4%) | 82 (51.2%) | 68 (51.5%) | 91 (56.6%) | ||||||||
0 = TT | 51 (17.4%) | 23 (14.4%) | 28 (21.2%) | 21 (13.4%) | ||||||||
AMPD1 | Adenosine Monophosphate Deaminase 1 | c.34C>T | rs17602729 | 2 = CC | 233 (79.8%) | 128 (80.0%) | 105 (79.6%) | 0.291 | 99 (62.1%) | 0.006 | 0.010 | 0.014 |
1 = CT | 57 (19.5%) | 32 (20.0%) | 25 (18.9%) | 60 (37.4%) | ||||||||
0 = TT | 2 (0.7%) | 0 (0.0%) | 2 (1.5%) | 1 (0.5%) | ||||||||
CKM | Muscle-specific creatine kinase | c.*800A>G | rs8111989 | 2 = GG | 26 (8.9%) | 16 (10.0%) | 10 (7.6%) | 0.418 | 10 (5.9%) | 0.718 | 0.326 | 0.384 |
1 = GA | 142 (48.6%) | 88 (55.0%) | 54 (40.9%) | 72 (45.3%) | ||||||||
0 = AA | 124 (42.5%) | 56 (35.0%) | 68 (51.5%) | 78 (48.8%) | ||||||||
MLCK | Myosin-light chain kinase | c.37885C>A | rs28497577 | 2 = AA | 1 (0.4%) | 0 (0.0%) | 1 (0.8%) | 0.002 | 1 (0.6%) | <0.001 | <0.001 | <0.001 |
1 = CA | 217 (74.3%) | 107 (66.9%) | 110 (83.3%) | 56 (35.3%) | ||||||||
0 = CC | 74 (25.3%) | 53 (33.1%) | 21 (15.9%) | 103 (64.1%) | ||||||||
MLCK | Myosin-light chain kinase | c.49C>T | rs2700352 | 2 = CC | 167 (57.2%) | 79 (49.4%) | 88 (66.7%) | 0.001 | 31 (19.6%) | <0.001 | <0.001 | <0.001 |
1 = CT | 99 (33.9%) | 59 (36.8%) | 40 (30.3%) | 109 (68.1%) | ||||||||
0 = TT | 26 (8.9%) | 22 (13.8%) | 4 (3.0%) | 20 (12.3%) |