Fig 4. Genotype-dependent sex differences in IAV susceptibility of B6.Chr^PWD consomic mice.

Male (M) and female (F) B6 control and B6.Chr5^PWD (A-D) and B6.ChrX.3^PWD (E-H) mice were infected with sex-adjusted doses of PR8 as in Fig 2B. The following comparisons were made: (A and E) male consomic vs. male B6 control, (B and F) female consomic vs. female B6 control, and (C, D, G and H) male vs. female of each consomic. Significance of difference in survival for each comparison assessed by Mantel-Cox test, while significance of difference in weight loss was assessed by two-way ANOVA (overall effect of sex). The P value for each comparison is indicated in each corresponding graph, in red font if below P<0.05. Complete data on survival analysis for all consomic strains are presented in Tables 1 and 2.