Table 1. Survival analysis of IAV-challenged consomic strains using pooled sex data.
The indicated number (N) of each strain were challenged with IAV as described in Fig 3. Male and female data were pooled. Significance of differences in survival between B6 and each consomic strain were assessed using the Mantel-Cox test and the P value are reported, with P<0.05 shown in bold font. Percent of mice surviving to the endpoint on day 20 is shown. Numbers of male and female mice studied are also shown. Data from for B6.Chr17PWD represent pooled data from Chr17S and Chr17F strains. The low N for some strains (Chr13, Chr7, etc.) was a result of low availability of animals due to poor breeding performance.
| Strain | Survival (P) | % Survived | N = | Male:Female |
|---|---|---|---|---|
| B6 | N/A | 79.4 | 63 | 24:39 |
| Chr1 | 0.0098 | 100.0 | 29 | 14:15 |
| Chr2 | 0.15 | 66.7 | 21 | 13:8 |
| Chr3 | <0.0001 | 6.3 | 16 | 9:7 |
| Chr5 | <0.0001 | 30.8 | 26 | 16:10 |
| Chr6 | 0.002 | 50.0 | 22 | 10:12 |
| Chr7 | 0.57 | 87.5 | 8 | 4:4 |
| Chr9 | 0.03 | 58.3 | 24 | 13:11 |
| Chr10.2 | 0.94 | 80.0 | 20 | 10:10 |
| Chr10.3 | 0.004 | 55.6 | 27 | 12:15 |
| Chr11.1 | 0.88 | 80.0 | 35 | 19:16 |
| Chr11.2 | 0.003 | 55.2 | 29 | 15:14 |
| Chr11.3 | 0.23 | 93.3 | 15 | 5:10 |
| Chr12 | 0.008 | 58.3 | 36 | 22:14 |
| Chr13 | 0.99 | 80.0 | 5 | 3:2 |
| Chr14 | 0.15 | 67.6 | 34 | 17:17 |
| Chr15 | 0.04 | 56.5 | 23 | 11:12 |
| Chr17 | 0.003 | 98.0 | 50 | 30:20 |
| Chr18 | 0.29 | 70.4 | 27 | 14:13 |
| Chr19 | 0.15 | 69.2 | 39 | 27:12 |
| ChrX.1 | 0.59 | 85.7 | 21 | 6:15 |
| ChrX.2 | 0.17 | 100.0 | 8 | 5:3 |
| ChrX.3 | 0.08 | 60.9 | 23 | 10:13 |
| mt | 0.76 | 82.1 | 28 | 11:17 |