Table 4. Sex-dependent DEGs mapping to the sex chromosomes.
Genes differentially expressed between males and females in: B6 mice only (B6; none in this category), ChrX.3 mice only (ChrX.3), or in both strains (both) which mapped to ChrX or ChrY, from the RNAseq data described in Fig 6. Direction of change: up indicates increased expression in males relative to females, down indicates increased expression in females relative to males. A cutoff filter of Padj = <0.05 was used to identify DEGs, without a fold change cutoff.
| Gene Symbol | Chr | Direction in males | Position on Chr (bp) | Strain in which differentially expressed | |
|---|---|---|---|---|---|
| Start | end | ||||
| Kdm6a | X | down | 18,162,575 | 18,279,936 | ChrX.3 |
| Gm2223 | X | down | 33,505,661 | 33,507,010 | ChrX.3 |
| Bgn | X | down | 73,483,602 | 73,495,933 | ChrX.3 |
| Eif2s3x | X | down | 94,188,709 | 94,212,651 | both |
| Xist | X | down | 103,460,373 | 103,483,233 | both |
| Slc25a53 | X | up | 136,981,116 | 137,038,302 | ChrX.3 |
| Kdm5c | X | down | 152,233,020 | 152,274,535 | both |
| Rps7-ps3 | X | down | 152,909,505 | 152,910,155 | ChrX.3 |
| Kdm5d | Y | up | 897,566 | 943,813 | both |
| Eif2s3y | Y | up | 1,010,543 | 1,028,847 | both |
| Uty | Y | up | 1,096,861 | 1,245,759 | both |
| Ddx3y | Y | up | 1,260,771 | 1,286,629 | both |