Table 3.

Cytotoxicity (IC₅₀ ± SD_, nM) and Potency (%)* of 1 g, 2e, and 2 l on EGFR, HER-2, and BTK compared with lapatinib.

Compound	EGFR		HER-2		BTK
	IC50 ± SD	Potency	IC50 ± SD	Potency	IC50 ± SD	Potency
1g	62.19 ± 0.76	87.44	70.55 ± 0.63	103.20	60.27 ± 0.42	101.99
2e	80.35 ± 1.26	67.68	76.54 ± 0.87	95.13	82.06 ± 1.40	74.91
2l	75.22 ± 0.95	72.29	81.72 ± 0.92	89.10	63.80 ± 0.55	96.35
Lapatinib	54.38 ± 0.7	100.0	72.81 ± 0.68	100.0	61.47 ± 0.58	100.0

*Potency (%) was calculated as ((IC₅₀ lapatinib/IC₅₀ Compound) *100).