Table 1. TRIM25-R54P interactors in the absence of virus.
Interactors pulled down in both independent experiments shown here; proteins also enriched in TRIM25-WT co-IP are italicized and bolded. Fold change = FC. In EXP #2, the “i” prefacing log2FC and Pvalue refers to how missing data values were imputed.
| Protein | EXP #1 log2FC | EXP #2 ilog2FC | EXP #1 -log10Pvalue | EXP #2 -log10iPvalue |
|---|---|---|---|---|
| TRIM25 | 12.39 | 7.51 | 4.29 | 2.12 |
| G3BP2 | 8.11 | 5.55 | 4.48 | 1.50 |
| G3BP1 | 6.50 | 4.03 | 3.78 | 1.73 |
| PABPC1 | 5.93 | 5.10 | 4.55 | 3.28 |
| UPF1 | 5.50 | 4.79 | 3.60 | 1.44 |
| RPL27 | 5.34 | 3.69 | 1.84 | 1.55 |
| ZC3HAV1 | 5.32 | 5.31 | 2.83 | 1.42 |
| ZCCHC3 | 5.12 | 3.75 | 1.85 | 1.78 |
| RPL36 | 4.98 | 3.48 | 2.88 | 1.79 |
| MOV10 | 4.91 | 4.49 | 1.64 | 1.80 |
| RPLP2 | 4.13 | 5.86 | 1.96 | 1.55 |
| SSB | 3.89 | 4.48 | 1.91 | 1.71 |
| RPS3A | 3.79 | 2.69 | 2.16 | 1.89 |
| MRPL11 | 3.77 | 5.47 | 2.66 | 1.40 |
| RPL3 | 3.66 | 2.15 | 2.24 | 1.79 |
| RPS12 | 3.66 | 3.49 | 2.76 | 1.89 |
| NME1 | 3.61 | 4.79 | 2.39 | 1.79 |
| IGF2BP3 | 3.56 | 3.28 | 1.98 | 1.50 |
| RPS8 | 3.26 | 3.27 | 2.19 | 1.75 |
| DNAJA1 | 3.17 | 3.92 | 2.61 | 1.91 |
| RPL21 | 3.06 | 2.39 | 1.48 | 1.47 |
| DDX21 | 3.05 | 1.89 | 1.59 | 1.73 |
| RPL7A | 3.04 | 2.52 | 2.05 | 1.73 |
| DDX50 | 3.03 | 3.66 | 1.48 | 1.53 |
| RPL14 | 3.01 | 2.79 | 1.83 | 1.79 |
| HSPA9 | 2.98 | 2.54 | 3.10 | 1.73 |
| RPL8 | 2.95 | 2.64 | 2.62 | 1.50 |
| RPL4 | 2.95 | 1.93 | 1.80 | 1.50 |
| RPL30 | 2.92 | 4.99 | 1.86 | 1.81 |
| RPL6 | 2.88 | 1.95 | 1.97 | 1.50 |
| RPL19 | 2.77 | 5.27 | 1.34 | 1.36 |
| CXorf56 | 2.62 | 2.59 | 1.71 | 1.34 |
| MRPS25 | 2.56 | 3.34 | 2.61 | 1.54 |
| POLDIP2 | 2.24 | 2.45 | 3.07 | 1.64 |
| IGF2BP2 | 2.20 | 3.23 | 2.15 | 1.46 |
| HSPA5 | 2.10 | 2.61 | 2.56 | 1.79 |
| NCL | 1.95 | 2.58 | 1.78 | 2.63 |
| HSPA8 | 1.64 | 2.01 | 2.45 | 1.79 |
| RTRAF | 1.60 | 1.76 | 1.84 | 1.31 |