Table 2. TRIM25-WT interactors in the absence of virus.
Interactors pulled down in both independent experiments shown here; proteins also enriched in TRIM25-R54P co-IP in both independent experiments are italicized and bolded. Fold change = FC. In EXP #2, the “i” prefacing log2FC and Pvalue refers to how missing data values were imputed.
| Protein | EXP #1 log2FC | EXP #2 ilog2FC | EXP #1 -log10Pvalue | EXP #2 -log10iPvalue |
|---|---|---|---|---|
| TRIM25 | 12.35 | 7.21 | 4.29 | 2.36 |
| NME1 | 5.89 | 5.69 | 3.19 | 2.11 |
| PABPC1 | 5.18 | 4.36 | 4.32 | 2.65 |
| UPF1 | 4.15 | 4.99 | 3.13 | 1.56 |
| G3BP1 | 3.84 | 4.38 | 2.89 | 2.08 |
| SSB | 3.67 | 5.28 | 1.82 | 1.67 |
| RPS12 | 3.52 | 3.02 | 2.70 | 2.24 |
| DDX21 | 3.52 | 1.60 | 1.79 | 2.07 |
| ZCCHC3 | 3.41 | 2.47 | 1.50 | 1.50 |
| MRPL11 | 3.11 | 4.50 | 2.36 | 1.83 |
| MRPS25 | 3.11 | 5.37 | 2.93 | 1.81 |
| RPS3A | 3.02 | 1.92 | 1.82 | 2.11 |
| RPL14 | 2.91 | 2.56 | 1.78 | 1.71 |
| RPS8 | 2.86 | 3.07 | 1.99 | 2.11 |
| RPL23A | 2.83 | 2.50 | 1.42 | 2.29 |
| LARP1 | 2.82 | 2.72 | 1.75 | 1.65 |
| HSPA9 | 2.78 | 2.55 | 2.98 | 1.98 |
| DDX50 | 2.78 | 5.52 | 1.38 | 1.87 |
| RPLP2 | 2.71 | 5.81 | 1.37 | 1.36 |
| RPL7A | 2.68 | 2.05 | 1.87 | 2.11 |
| RPL8 | 2.67 | 1.91 | 2.46 | 1.46 |
| IGF2BP3 | 2.67 | 3.65 | 1.56 | 1.66 |
| HSPA5 | 2.36 | 2.77 | 2.75 | 2.05 |
| FMR1 | 2.16 | 2.14 | 1.38 | 1.56 |
| RPL4 | 2.09 | 1.96 | 1.33 | 2.08 |
| RPL30 | 1.98 | 4.99 | 1.33 | 2.66 |
| RPL32 | 1.91 | 2.10 | 1.44 | 2.05 |
| IGF2BP2 | 1.73 | 2.16 | 1.80 | 1.45 |
| HSPA8 | 1.66 | 2.26 | 2.46 | 1.65 |
| FXR1 | 1.52 | 4.86 | 2.66 | 1.59 |