Table 2.
Colorectal Neoplastic Findings in Those Having Follow-Up Colonoscopy for Positive mt-sDNA Test With or Without Prior Radiation Therapy
| Finding | Radiation therapy (RT) mt-sDNA (n = 220) | Eckmann et ald (n = 16,249) | Imperiale et al (n = 9989) |
P value RT mt-sDNA compared to: |
|
|---|---|---|---|---|---|
| Eckmann et ald | Imperiale et al | ||||
| Positive mT-sDNA, n (%) | 45 (20) | 2280 (14) | 1612 (16) | .01 | .10 |
| Colonoscopy compliancea, n (%) | 42 (93) | 1523 (86)b | 9989 (100) | .26 | N/A |
| Any colorectal neoplasia, n (%) | 31 (74) | 1020 (67) | 879 (55) | .41 | <.0001 |
| Colorectal cancer, n (%) | 0 (0) | 14 (1) | 60 (4) | 1.00 | .40 |
| Advanced colorectal neoplasiac, n (%) | 15 (38) | 415 (27) | 321 (20) | .22 | .02 |
| Nonadvanced neoplasia, n (%) | 16 (38) | 591 (39) | 498 (31) | 1.00 | .32 |
| No neoplasia, n (%) | 11 (26) | 503 (33) | 733 (45) | .41 | .02 |
| ≥3 polypse <10 mm, n (%) | 7 (18) | 154 (10) | Not reported | .19 | N/A |
| 1–2 polyps 6–9 mm, n (%) | 5 (12) | 163 (11) | Not reported | .80 | N/A |
| 1–2 polyps ≤5 mm, n (%) | 4 (10) | 274 (18) | Not reported | .22 | N/A |
One additional patient was reported to have undergone post-mt-sDNA, colonoscopy at another center but this could not be confirmed.
Test positive analysis excluded 220 patients that were at increased risk for colorectal cancer and 297 patients that denied consent for research or did not meet inclusion criteria.
Adenoma/sessile serrated polyps ≥1 cm or with high grade dysplasia or villous elements.
Among this published cohort, patients with history of radiation therapy and subsequent mt-sDNA, use were removed and included only in the RT, group.
Polyp refers to tubular adenoma or sessile serrated adenoma; Eckmann paper reported CRC, with advanced neoplasia.