Table 2.
Multivariable mixed effects model for tacrolimus concentration/dose ratio (C0/D).
| Variable | Percentage change in C0/D (95% CI)a |
|---|---|
| Anemia | -4.01 (-10.96–3.48) |
| Postoperative day | 0.04 (0.02–0.06)∗ |
| RBCb | 22.17 (14.98–29.82)∗∗ |
| HGB | 0.07 (-0.10–0.24) |
| ALB | 2.19 (1.72–2.67)∗∗ |
| WZC | 27.2 (19.39–35.52)∗∗ |
| CYP3A5 genotype (rs776746)c | |
| Poor metabolizers | Reference |
| Intermediate metabolizers | -22.39 (-27.82 to -16.56)∗∗ |
| Extensive metabolizers | -40.89 (-47.62 to -33.29)∗∗ |
| ABCB1 (rs1128503) | |
| TT | Reference |
| CT | -5.21 (-12.07–2.18) |
| CC | -11.43 (-20.11 to -1.81) |
| ABCB1 (rs2032582) | |
| GG | Reference |
| GA | 8.19 (-0.52–17.66) |
| AA | 16.52 (4.11–30.42)∗∗ |
| ABCB1 (rs1045642) | |
| TT | Reference |
| CT | -14.59 (-23.18 to -5.03)∗∗ |
| CC | -15.03 (-24.75 to -4.05)∗∗ |
| ABCC2 (rs2273697) | |
| GG | Reference |
| GA | 1.97 (-22.92–24.65) |
| AA | 8.98 (-13.14–36.73) |
| ABCC2 (rs3740066)d | |
| CC | Reference |
| CT | 5.59 (-7.32–20.29) |
| TT | 14.42 (0.48–30.29)∗ |
| POR28 (rs1057868) | |
| CC | Reference |
| CT | -5.41 (-14.41–4.53) |
| TT | -7.54 (-16.56–2.46) |
| PXR (rs6785049) | |
| GG | Reference |
| GA | -6.12 (-15.82–4.68) |
| AA | -5.90 (-15.22–4.43) |
RBC: red blood cell; HGB: Hemoglobin; ALT: alanine aminotransferase; ALB: albumin; WZC: Wuzhi capsule. aAnalysis based on log-transformed C0/D. Model coefficients were exponentiated to provide the percentage change in C0/D for a one-unit change in each covariate, unless otherwise specified. Increases in C0/D signify decreased tacrolimus clearance. bSerious collinearity between RBC and HCT was observed, and consequently only RBC was retained. cPoor metabolizers defined as CYP3A5∗3/∗3 (GG); intermediate metabolizers defined as CYP3A5∗1∗3 (AG); extensive metabolizers defined as CYP3A5∗1∗1 (AA). dSerious collinearity between ABCC2 (rs3740066) and ABCC2 (rs717620) was observed, and consequently, only ABCC2 (rs3740066) was retained. ∗p < 0.05; ∗∗p < 0.01.