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. 2022 Aug 9;41(38):4336–4348. doi: 10.1038/s41388-022-02426-3

Fig. 7. Schematic of the mechanism by which cytoplasmic PURα inhibits mRNA translation to mediate ESCC progression.

Fig. 7

As a novel component of cytoplasmic stress granules, PURα preferentially binds to UG-/U-rich motifs located in the 3’UTRs of mRNAs and recruits translation initiation factors to attenuate mRNA translation.