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. 2022 Sep 16;79(10):521. doi: 10.1007/s00018-022-04540-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Methylation levels of CAT promoter region in HD and CLL B cells. A Methylation levels of the analyzed CAT promoter in HD B cells (n = 10) compared with CLL cells (n = 21). DNA methylation levels were measured as mean among the analyzed sites. Data are expressed as mean ± SEM. Comparison was performed with Student t test. **P < 0.01. B and C Correlation matrices showing pairwise Pearson correlations of methylation status among the 8 CpG sites within the promoter region of human CAT gene in HD (B) and CLL B cells (C). HDs healthy donors, CLL chronic lymphocytic leukemia