Table 4.
Univariable and multivariable analyses for overall survival and recurrence-free survival in patients with high-risk score (M-CS 2–3)
| Variables | Overall survival | Recurrence-free survival | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariable | Multivariable | Univariable | Multivariable | |||||||||
| HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | |
| Sex (female vs. male) | 0.88 | 0.63–1.23 | 0.458 | 1.01 | 0.77–1.34 | 0.926 | ||||||
| Age (≥ 65 years) | 1.03 | 0.70–1.52 | 0.895 | 1.15 | 0.83–1.60 | 0.388 | ||||||
| ASA score(III/I,II) | 0.94 | 0.74–1.20 | 0.613 | 1.10 | 0.91–1.33 | 0.349 | ||||||
| Primary tumor | ||||||||||||
| Site (right vs. left) | 0.94 | 0.64–1.37 | 0.734 | 0.91 | 0.66–1.25 | 0.565 | ||||||
| T category (T3-4 vs. T1-2) | 1.38 | 0.65–2.95 | 0.408 | 1.50 | 0.82–2.75 | 0.167 | ||||||
| N category (N1-2 vs. N0) | 1.04 | 0.51–2.12 | 0.922 | 1.50 | 0.79–2.82 | 0.214 | ||||||
| CRLM characteristics | ||||||||||||
| Tumor number (multiple) | 1.21 | 0.86–1.71 | 0.269 | 1.70 | 1.27–2.26 | 0.000 | 1.36 | 0.91–2.02 | 0.132 | |||
| Maximum tumor size ≥ 5 cm | 1.08 | 0.76–1.53 | 0.671 | 1.07 | 0.80–1.43 | 0.638 | ||||||
| Distribution (bilobar vs. unilobar) | 1.35 | 0.97–1.87 | 0.077 | 1.64 | 1.25–2.15 | 0.000 | 1.25 | 0.87–1.80 | 0.232 | |||
| Ras status (mutation vs. wild type) | 1.34 | 0.91–1.99 | 0.143 | 1.23 | 0.89–1.70 | 0.209 | ||||||
| Preoperative factors | ||||||||||||
| Preoperative chemotherapy (yes vs. no) | 1.05 | 0.74–1.49 | 0.794 | 0.89 | 0.66–1.20 | 0.429 | ||||||
| CEA, ng/mL (< 20 vs. ≥ 20) | 1.32 | 0.95–1.83 | 0.103 | 1.58 | 1.21–2.08 | 0.001 | 1.48 | 1.13–1.96 | 0.005 | |||
| Synchronous metastasis | 1.18 | 0.85–1.65 | 0.320 | 1.57 | 1.19–2.06 | 0.001 | 1.31 | 0.96–1.79 | 0.084 | |||
| Extrahepatic metastasis | 1.25 | 1.02–1.54 | 0.034 | 1.27 | 1.03–1.57 | 0.026 | 1.12 | 0.94–1.33 | 0.206 | |||
| Surgical factors | ||||||||||||
| Intraoperative ablation | 0.83 | 0.47–1.46 | 0.512 | 1.07 | 0.71–1.62 | 0.741 | ||||||
| Intraoperative blood transfusion | 1.40 | 0.85–2.29 | 0.187 | 1.11 | 0.70–1.76 | 0.665 | ||||||
| Major resection | 1.34 | 0.90–1.97 | 0.147 | 1.15 | 0.82–1.61 | 0.432 | ||||||
| Resection margin width, mm (< 1 vs. ≥ 1) | 1.28 | 0.90–1.83 | 0.176 | 1.11 | 0.82–1.51 | 0.487 | ||||||
| High CCI | 1.61 | 1.12–2.30 | 0.010 | 1.44 | 0.99–2.10 | 0.054 | 1.35 | 0.99–1.86 | 0.060 | 1.02 | 0.73–1.43 | 0.893 |
| Infectious complication | 1.23 | 1.01–1.49 | 0.036 | 1.17 | 0.96–1.43 | 0.120 | 1.16 | 0.98–1.37 | 0.084 | 1.02 | 0.86–1.22 | 0.805 |
| Major complication | 1.16 | 0.94–1.42 | 0.179 | 1.08 | 0.90–1.30 | 0.384 | ||||||
| Adjuvant chemotherapy (yes vs. no) | 0.73 | 0.52–1.03 | 0.076 | 0.71 | 0.50–1.01 | 0.057 | 0.71 | 0.53–0.95 | 0.022 | 0.65 | 0.48–0.88 | 0.005 |