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. 2022 Sep 16;12:15612. doi: 10.1038/s41598-022-19993-w

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© The Author(s) 2022, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Sotrovimab mAb has no potential to cause ADE of infection. Clone 35 cells (2 × 10⁴/well in a 96-well flat plate) were cultured with SARS-CoV-2 (original or Omicron strain) in the presence (N = 3) or absence (N = 3–6, control culture) of serially-diluted Cas (A,C) or Sot (B,D) mAb. Three days later, the amount of virus in culture SNs was measured by qPCR. The increase of virus progeny in SNs is expressed as the fold increase compared with the amount of viruses cultured in the absence of mAb on a linear scale (A,B) or log scale (C,D).