Fig. 4. Predicted risk of disease onset over age for the top two loci in the GWAS of four phenotypes in the UK Biobank data with White British ancestry.

Predicted risk of disease onset is plotted over age by genotypes for loci LPA and CELSR2 for ischemic heart disease, FGFR2 and CASC16 for female breast cancer, MYOC and TMCO1 for glaucoma, and APOE e4 variant for AD. The red, green, and blue lines represent the risk of disease onset for alternate allele counts zero, one, and two, respectively, for a female subject born in 1950 (median birth year in the UKBB data) with the top four PC coordinates each set at the mean level across the UK Biobank subjects with white British ancestry.