Table 1.
Demographics, cognitive function and biological measures in patients defined as stable MCI and converters to AD.
sMCI (N = 357) | cAD (N = 321) | t/ | p value | Effect size | |
---|---|---|---|---|---|
Mean (SD) | Mean (SD) | ||||
Demographics | |||||
Age | 73.1 (7.45) | 73.9 (7.11) | 1.35 | 0.176 | 0.10 |
Gender (%F) | 41.2 | 38.9 | 0.352 | 0.553 | 0.02 |
Cognitive function | |||||
RAVLT-Im | 36.9 (10.5) | 29.3 (7.7) | 10.56 | < 0.001 | 0.81 |
RAVLT-delay | 4.88 (3.93) | 2.05 (2.67) | 10.87 | < 0.001 | 0.84 |
RAVLT-recog | 11.26 (3.16) | 9.42 (3.56) | 7.13 | < 0.001 | 0.55 |
TMTA | 39.2 (15.6) | 44.7 (21.5) | 3.90 | < 0.001 | 0.30 |
TMTB | 108.1 (56.9) | 133.8 (73.9) | 5.10 | < 0.001 | 0.39 |
CFT animals | 17.8 (5.17) | 15.8 (4.75) | 5.13 | < 0.001 | 0.39 |
GDS: mean (SD) | 1.71 (1.44) | 1.65 (1.38) | 0.53 | 0.596 | 0.04 |
ANART Total errors | 12.9 (9.3) | 13.3 (9.6) | 0.61 | 0.539 | 0.05 |
Biological measures | |||||
Hippocampus volume | 0.00451 (7.6) | 0.00398 (6.8) | 9.64 | < 0.001 | 0.74 |
APOE (%positive) | 42.3 | 64.2 | 32.45 | < 0.001 | 0.22 |
sMCI stable Mild Cognitive Impairment, cAD converted to Alzheimer’s disease, RAVLT Rey Auditory Verbal Learning Test, TMT Trail Making Test, CTF Category Fluency Test, GDS Geriatric Depression Scale, ANART American National Reading Test.