Table 2.
Demographics, cognitive function and biological measures in correctly and misclassified patients.
| TN (n = 54) | FP (n = 20) | FN (n = 24) | TP (n = 41) | ||
|---|---|---|---|---|---|
| Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | ||
| Demographics | |||||
| Age | 72.1 (7.32) | 74.9 (7.19) | 74.8 (8.01) | 73.3 (7.61) | – |
| Gender (% F) | 38.9 | 55.0 | 29.2 | 43.9 | – |
| Cognitive function | |||||
| RAVLT-Im | 39.15 (8.85) | 30.60 (7.23) | 35.38 (7.60) | 28.12 (4.83) | a, b |
| RAVLT-delay | 5.89 (3.41) | 1.20 (1.54) | 4.38 (3.00) | 1.24 (1.55) | a, b |
| RAVLT-recog | 12.15 (2.66) | 9.40 (3.42) | 11.71 (2.60) | 8.66 (3.63) | a, b |
| TMTA | 37.2 (13.1) | 40.8 (8.3) | 42.6 (28.9) | 45.1 (25.8) | – |
| TMTB | 91.6 (31.9) | 129.6 (61.3) | 130.0 (88.6) | 134.4 (77.4) | a |
| CFT animals | 18.69 (4.82) | 16.80 (5.35) | 16.00 (4.23) | 15.81 (4.24) | – |
| GDS | 1.82 (1.35) | 1.85 (1.14) | 1.29 (1.12) | 1.51 (1.25) | – |
| ANART total errors | 13.0 (9.7) | 9.2 (7.3) | 13.0 (9.9) | 13.3 (10.3) | – |
| Biological measures | |||||
| Hippocampus volume | 0.00457 (7.4*10) | 0.00384(6.1*10) | 0.00439 (6.2*10) | 0.00372 (6.8*10) | a, b |
| APOE (% positive) | 37.0 | 55.0 | 45.8 | 78.0 | – |
TN correctly classified sMCI, FP sMCI subjects misclassified converters, FN cAD subjects misclassified as stable, TP cAD subjects correctly classified, RAVLT Rey Auditory Verbal Learning Test, TMT Trail Making Test, CTF Category Fluency Test, GDS Geriatric Depression Scale, ANART American National Reading Test. Multiple comparisons abbreviated as: a = TN differ from FP; b = FN differ from TP. Group mean differences at Bonferroni corrected alpha level of 0.004 , rounded) considered statistically significant.