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. 2022 Sep 16;7:53. doi: 10.1038/s41536-022-00250-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Heatmap of clustering dysregulated miRNA expression profiles with microarray in T3-EVs compared to untreated un-EV control. B Volcano plot of miRNA expression profiles and miR-455 (red dot) was most significantly upregulated in T3-EV. C–E All differentially expressed miRNAs(DEG with fold change >2 or <0.5, p value <0.01) were subjected to gene ontology (GO) analysis for C biological processes, D molecular function, and E cellular component. F Significantly enriched pathways for target genes of miRNAs enriched within T3-EV in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. G miRNAs expression elevation (n = 3 for each) with the same EVs was validated with qRT-PCR. *P < 0.05, **P < 0.01, ***P < 0.001, NS not significant.