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α-Chymotrypsin inhibitory activity of Ugi adducts derived from plant products.
| Compound | % Inhibition (10 μM)a | IC50 (μM)a |
|---|---|---|
| 2 | 9.2 ± 1.6 | – |
| 4 | 3.1 ± 0.9 | – |
| 5 | 4.2 ± 1.7 | – |
| 7 | 90.4 ± 1.1 | 3.1 ± 0.1 |
| 8a | 57.8 ± 2.4 | 7.3 ± 0.6 |
| 8b | 48.5 ± 2.6 | 13.4 ± 1.3 |
| 9 | 55.9 ± 1.9 | 7.9 ± 0.5 |
| 10 | 53.1 ± 1.3 | 7.7 ± 0.6 |
| Chymostatin | 18.5 ± 1.1b |
aData represent the mean ± SE of at least three independent experiments. bnM.
