Table 2.
Associations between hypertension and liver-related outcomes using both measured blood pressure, use of antihypertensive medication and polygenic risk scores (PRSs).
| n/N | HRa (95% CI) | P | HRb (95% CI) | P | |
|---|---|---|---|---|---|
| Measured SBP (per 1 SD) | 441/33,770 | 1.22 (1.10–1.34) | < 0.001 | 1.16 (1.03–1.30) | 0.01 |
| Measured DBP (per 1 SD) | 441/33,770 | 1.17 (1.07–1.29) | 0.001 | 1.06 (0.95–1.20) | 0.29 |
| Measured pulse pressure (per 1 SD) | 441/33,770 | 1.12 (1.02–1.23) | 0.019 | 1.12 (1.00–1.24) | 0.04 |
| Elevated blood pressurec | |||||
| No | 61/9602 | 1.00 | 1.00 | ||
| Yes | 380/24,140 | 1.92 (1.44–2.54) | < 0.001 | 1.79 (1.27–2.51) | 0.001 |
| HTA statusd | |||||
| Normal blood pressure, no medication | 104/11,361 | 1.00 | 1.00 | ||
| High blood pressure, previously unknown | 72/4444 | 1.47 (1.07–2.01) | 0.02 | 1.73 (1.20–2.49) | 0.003 |
| High blood pressure, previously known, no medication | 70/3304 | 2.07 (1.51–2.83) | < 0.001 | 1.67 (1.12–2.48) | 0.01 |
| High blood pressure despite medication | 40/2478 | 1.86 (1.25–2.76) | 0.002 | 1.75 (1.08–2.86) | 0.02 |
| Normal blood pressure during medication | 9/870 | 1.57 (0.78–3.14) | 0.21 | 1.48 (0.63–3.51) | 0.37 |
| SBP PRS (per 1 SD) | 441/33,770 | 1.12 (1.02–1.23) | 0.02 | 1.19 (1.01–1.24) | 0.04 |
| DBP PRS (per 1 SD) | 441/33,770 | 1.13 (1.03–1.24) | 0.01 | 1.12 (1.01–1.25) | 0.03 |
Analyses are by Cox regression analyses.
CI, confidence interval; HR, hazards ratio; HTA, arterial hypertension; SBP, systolic blood pressure; DBP, diastolic blood pressure; PRS, polygenic risk score.
aAdjusted for age and sex. Analyses including polygenic risk scores (PRS) are additionally adjusted for genotyping chip and the first three principal components of genetic structure.
bAdjusted for age, sex, body mass index, waist circumference, weekly alcohol use, fraction of alcohol use as wine, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, diabetes, exercise habits, smoking status (current, former, never smoker) and baseline cardiovascular disease. Analyses including polygenic risk scores (PRS) are additionally adjusted for genotyping chip and the first three principal components of genetic structure.
cEither measured blood pressure ≥ 130 (systolic) or ≥ 85 (diastolic) mmHg or antihypertensive medication use at baseline.
dHigh blood pressure defined as ≥ 140 (systolic) or ≥ 90 (diastolic) mmHg.