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. 2022 Sep 16;12:15593. doi: 10.1038/s41598-022-18716-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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NfL as a predictor of CIPN and paclitaxel dose reduction over duration of the trial. (a) Summary of NfL change at C2D1 by highest grade of CIPN reported for all subjects. (b) NfL change in subjects that reported grade 2–3 CIPN after C2D1, excluding subjects already reporting such events. (c) Reduction of cumulative paclitaxel dose by NfL change *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 by Dunn’s test panel (a) and (c) or Wilcoxon rank sum test panel (b).