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. Author manuscript; available in PMC: 2023 Sep 15.
Published in final edited form as: Mol Cell. 2022 Jul 15:S1097-2765(22)00612-8. doi: 10.1016/j.molcel.2022.06.029

Figure 1. A comprehensive map of TF motifs in the mouse and human genomes.

Figure 1.

(A) JASPAR, TRANSFAC, and CIS-BP databases were merged to define 3,756 and 5,937 PWMs for mouse and human TFs respectively. Analysis of the two genomes resulted in 254 and 535 million TF binding motifs. Based on DHS and ATAC-Seq data, 76 and 182 million motifs were identified in accessible DNA in the two genomes. (B) Bar graph showing the number of accessible DNA elements found in a single cell type (unique), shared between multiple cell types, or present in all cell types (common) in mice and humans. Throughout the text, DNA elements refer to 201bp ATAC-Seq (or DHS-Seq) or summits, detected by MACS2. (C) Pie charts show the percentage of cell-specific or common DNA elements associated with or distal to promoters in the mouse genome.