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. Author manuscript; available in PMC: 2023 Sep 15.
Published in final edited form as: Mol Cell. 2022 Jul 15:S1097-2765(22)00612-8. doi: 10.1016/j.molcel.2022.06.029

Figure 5. USFs provide accessibility to regulatory DNA.

Figure 5.

(A) Experimental strategy to assess accessibility at ATAC-Seq peaks where a single SNPs impacts recruitment of USFs or non-SFs. Mice images were obtained from the Jackson lab with permission. (B) Bar graph shows fold change in ATAC-Seq signals at elements where SNPs reduce occupancy of USFs (pink) or non-SF (grey) controls in F1 B cells. (C) Examples of ATAC-Seq peaks carrying single SNPs targeting SP1 (left) or NRF1 (right) binding motifs. BALB/c and Castaneous alleles are depicted in black and purple respectively.