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. 2022 Aug 5;42(9):741–753. doi: 10.1002/phar.2722

TABLE 2.

Assessment of bias in the included studies using ROBINS‐I

Study Bias of confounding variables Bias of selection of participants into the study Bias in classification from intended intervention Bias due to deviation from intended intervention Bias due to missing data Bias in measurement of outcomes Bias in selection of reporting results Overall assessment of high degree of bias
D'Amico 2021 25 High Low Low Low Low Low Low I
Eads 2021 26 High Low Low Low Low Low Low I
Lines 2021 27 High High High Low High Moderate High IIIII a
Muklewicz 2021 28 High Low Low Low Low Low Low I
Wolfe 2021 29 High Low Low Low Low Low Low I
Oda 2020 30 High High Low Low Moderate Low Low II
Vali 2020 31 High Low Low Low Low Moderate Low I
Meng 2019 34 High Low Low Low Low Moderate Low I
Neely 2018 32 High Low Low Moderate Low Moderate Low I
Finch 2017 33 High Low Low Low Low Low Low I
a

Overall high risk of bias, as defined by high risk of bias in 3 or more categories.