TABLE A2.

AKI definitions

Criteria	Definition
AKIN
Stage 1	Absolute increase in SCr >0.3 mg/dl or >1.5–2× from baseline Urine output <0.5 ml/kg per hour for >6 h
Stage 2	Increase in SCr >2–3× from baseline Urine output <0.5 ml/kg per hour for >12 h
Stage 3	Increase in SCr >3× from baseline or >4 mg/dl with acute increase >0.5 mg/dl Urine output <0.3 ml/kg per hour for >24 h, or anuria for 12 h
KDIGO
Stage 1	Increase in SCr by 1.5–1.9× from baseline or >0.3 mg/dl Urine output <0.5 ml/kg per hour for 6–12 h
Stage 2	Increase in SCr by 2–2.9× from baseline Urine output <0.5 ml/kg per hour for >12 h
Stage 3	Increase in SCr by 3× from baseline or >4 mg/dl Initiation of renal replacement therapy In patients <18 years, decrease in eGFR to <35 ml/min/1.73m2 Urine output <0.3 ml/kg per hour for >24 h, or anuria for >12 h
RIFLE
Risk	SCr 1.5–2× above baseline GFR decrease >25% Urine output <0.5 ml/kg per hour for 6 h
Injury	SCr 2–3× above baseline GFR decrease >50% Urine output <0.5 ml/kg per hour for 12 h
Failure	SCr more than 3× above baseline, >4 mg/dl, or acute rise >0.5 mg/dl GFR decrease >75% Urine output <0.3 ml/kg per hour for 24 h or anuria for 12 h
Loss	Persistent AKI (on renal replacement therapy for >4 weeks)
ESRD	On dialysis for >3 months
2020 Vancomycin consensus guidelines	A minimum of 2–3 consecutive documented increases in SCr (>0.5 mg/dl or >50% from baseline, whichever is greater) after several days of vancomycin therapy

Note: Summary of the AKI Definitions for AKIN, KDIGO, RIFLE, and 2009 Vancomycin Consensus Guidelines.

Abbreviations: AKI, acute kidney injury; AKIN, Acute Kidney Injury Network; ESRD, end‐stage renal disease; GFR, glomerular filtration rate; KDIGO, Kidney Disease: Improving Global Outcomes; kg, kilograms; ml, milliliters; RIFLE, Risk, Injury, Failure, Loss, End‐stage kidney disease; SCr, serum creatinine.