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. Author manuscript; available in PMC: 2023 Oct 1.
Published in final edited form as: Am J Surg Pathol. 2022 Jun 20:10.1097/PAS.0000000000001929. doi: 10.1097/PAS.0000000000001929

Table 1.

Clinical features, including treatment and follow up, for NTRK-rearranged uterine sarcomas of the cohort.

Case Age (years) Presentation Site Size (cm) FIGO Stage Surgical Therapy or Procedure Adjuvant Therapy Recurrence Time to Recurrence (months) Follow up (months) Status
1 35 Anemia, “fibroid” Corpus 5.1 IB Myomectomy NK NK NA NA LTFU
2 35 Dysmenorrhea, dyspareunia Cervix 3.5 IA TAH BSO NK NK NA NA LTFU
3 47 Mass Cervix 7.8 IB TAH BSO, bilateral pelvic & para-aortic nodes Radiation & chemotherapy NK NA 12 DOD
4 30 Enlarged, vascular, friable cervix Cervix 4.0 IIB TAH BS & omentectomy N N NA 35 NED
5 39 NK Cervix NK NK Local excision NK NK NA NA LTFU
6 16 NK Cervix NK IA Biopsy, LEEP, CKC N N NA 30 NED
7 26 NK Cervix 12 IIB TAH BS Radiation Pelvis 13 82 NED
8 26 NK Cervix 5.5 ≥IB TAH Radiation & chemotherapy Peritoneum, lymph nodes, bone 6 22 DOD
9 26 NK Cervix NK NK Local excision NK Lung 72 84 DOD
10 61 Vaginal bleeding Cervix 7 IB TAH BSO N N NA 16 NED
11 24 NK Cervix NK IA Local excision N N NA 16.5 NED
12 42 NK Cervix NK NK Local excision NK NK NA NA LTFU
13 42 Vaginal bleeding Cervix 5.6 IB TAH BSO N N NA 44 NED
14 46 NK Cervix 10.0 IB Radical hysterectomy BSO Radiation* NK NA NA LTFU
15 26 Vaginal bleeding Cervix 8.0 NK Cervical biopsy NK NK NA NA LTFU
*

neoadjuvant radiation therapy; LEEP = loop electrosurgical excision procedure; CKC = cold knife cone biopsy; LTFU = lost to follow up; NED = no evidence of disease; DOD = died of disease; NA = not applicable; NK = not known; TAH = total abdominal hysterectomy; BSO = bilateral salpingo-oophorectomy; BS = bilateral salpingectomy