Table 4.
Previously reported cases of NTRK-rearranged uterine sarcomas.
| Case | Series | Age (y) | Site | Stage | Time to recurrence (mo) | FU (mo) | FU status | Size (cm) | Atypia | Necrosis | LVI | Mitoses/10 HPF | Fusion |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Chiang1 | 46 | Cervix | IB | 7 | 7 | AWD | 9.3 | 2 | Y | N | 15 | TPM3∷NTRK1 |
| 2 | Chiang1 | 27 | Corpus | IB | NA | 11 | NED | 16.3 | 2 | N | N | 7 | LMNA∷NTRK1 |
| 3 | Chiang1 | 47 | Cervix | IB | 12 | 78 | DOD | 14 | 2 | Y | N | 12 | RBPMS∷NTRK3 |
| 4 | Chiang1 | 42 | Cervix | IB | NA | 2 | NED | 2.6 | 3 | N | N | 30 | TPR∷NTRK1 |
| 5 | Goulding26 | 13 | Cervix | IB | NA | 4 | NED | 9.2 | 1 | NA | NA | NA | TPM3∷NTRK1 |
| 6 | Boyle7 | 42 | Cervix | IB | NA | 11 | NED | 5.2 | 1 | N | NA | 8 | TPM3∷NTRK1 |
| 7 | Croce4 | 39 | Cervix | NA | NA | 0 | LTFU | NA | 1 | Y | N | 3 | TPM3∷NTRK1 |
| 8 | Croce4 | 44 | Cervix | IA | NA | 2 | NED | 4.5 | 2 | N | N | 3 | TPM3∷NTRK1 |
| 9 | Croce4 | 26 | Cervix | IB | NA | 52 | AWD | 12 | 2 | Y | N | 3 | EML4∷NTRK3 |
| 10 | Croce4 | 23 | Cervix | IA | NA | 33 | NED | 3 | 2 | Y | N | 5 | TPM3∷NTRK1 |
| 11† | Croce4, Mills14, Devereaux3 | 32 | Cervix | IA | NA | 156 | NED | 5 | 1 | N | N | 2 | TPM3∷NTRK1 |
| 12† | Croce4, Mills14, Devereaux3 | 21 | Cervix | IIB | 7 | 16 | DOD | 8.0 | 1–2 | Y | Y | 4 | TPM3∷NTRK1 |
| 13† | Croce4, Rabban5, Devereaux3, | 30 | Cervix | IA | 35 | 37 | AWD | 2.5 | 1 | N | N | 18 | TPM3∷NTRK1 |
| 14† | Rabban5, Devereaux3 | 24 | Cervix | IB | 16 | 52 | AWD | 15 | 1–2 | N | Y | 12 | SPECC1L∷NTRK3 |
| 15 | Rabban5 | 49 | Cervix | NA | NA | ≥6 | NED | 1.8 and 1.4 | 1–2 | N | N | 0 | TPR∷NTRK1 |
| 16 | Hodgson8 | 50s‡ | Cervix | IA | NA | 8 | NED | 1.6 | 1–2 | N | N | 0 | SPECC1L∷NTRK3 |
| 17 | Wong10 | 31 | Cervix | NA | NA | 0 | LTFU | 9 | NA | N | NA | 15 | NTRK3 * |
| 18 | Michal9 | 26 | Uterus | ≥IB | NA | 36 | NED | 23 | 1 | N | NA | 0 | STRN∷NTRK3 |
| 19 | Wells6 | 30 | Corpus | IB | NA | 4 | NED | 2.5 | 1–2 | N | N | 2 | TPM3∷NTRK1 |
| 20 | Gatalica2 | NA | Cervix | NA | NA | NA | NA | NA | NA | NA | NA | NA | TPM3∷NTRK1 |
| 21 | Gatalica2 | NA | Uterus | NA | NA | NA | NA | NA | NA | NA | NA | NA | SPECC1L∷NTRK3 |
| 22 | Devereaux3 | 39 | Cervix | IB | NA | 9 | NED | 5.8 | 1–2 | Y | N | 12 | TPM3∷NTRK1 |
| 23 | Devereaux3 | 66 | Cervix | IA | NA | 2 | NED | 1.5 | 1–2 | N | N | 1 | TPM3∷NTRK1 |
| 24 | Devereaux3 | 40 | Cervix | IA | NA | 32 | NED | 2 | 2 | N | N | 1 | TPR∷NTRK1 |
| 25 | Devereaux3 | 37 | Cervix | ≥IB | NA | 0 | LTFU | 6.3 | 1–2 | Y | N | 2 | IRF2BP2∷NTRK1 |
| 26 | Devereaux3 | 35 | Corpus | IB | NA | 31 | NED | 9.4 | 2–3 | N | N | 5 | C16orf72∷NTRK1 |
| 27 | Nilforoushan11 | 54 | Cervix | IB | 8 | 8 | AWD | 5.4 | 2 | Y | NA | 40 | SPECC1L∷NTRK3 |
| 28 | Nilforoushan11 | 52 | Cervix | IA | NA | 6 | NED | 1.3 | 1 | NA | NA | 1 | TPM3∷NTRK1 |
| 29 | Moh13 | 69 | Corpus | IB | NA | 12 | NED | 7 | 3 | Y | Y | 15 | WWOX∷NTRK2 |
| 30 | Tsai12 | 47 | Cervix | NA | 12 | 21 | AWD | 2.7 | 2–3 | Y | NA | 3 | TPM3∷NTRK1 |
| 31 | Tsai12 | 53 | Cervix | NA | 9 | 9 | AWD | 6.8 | 2–3 | Y | NA | 26 | TPM3∷NTRK1 |
*
Fusion partner not identified.
†
These cases have been reported in more than one series.
‡
The original report gave the patient age as “6th decade” and for multivariable analysis, the age was estimated as 55. LTFU = lost to follow up; NED = no evidence of disease; DOD = died of disease; NA = not applicable; HPF = high power fields