Table 5.
Cox proportional hazard analysis for disease free survival (DFS) and overall survival (OS) of NTRK-rearranged uterine sarcomas. HR: hazard ratio, CI: confidence interval. For continuous risk factors, the hazard ratio is for a 1-unit increase in the risk factor. For categorical variables, the comparison and reference groups are included in parentheses.
| Univariate | DFS | OS | ||||
|---|---|---|---|---|---|---|
| HR | CI (95%) | p | HR | CI (95%) | p | |
| Age (years) | 1.02 | 0.98–1.06 | 0.42 | 1.02 | 0.94–1.11 | 0.654 |
| Stage (≥1B vs 1A) | 5.9 | 0.81–42 | 0.076 | Not estimable* | ||
| Size (cm) | 1.02 | 0.91–1.13 | 0.78 | 1.02 | 0.85–1.24 | 0.82 |
| Mitoses/10 HPFs | 1.07 | 1.02–1.12 | 0.009 | 1.05 | 0.99–1.12 | 0.12 |
| Lymphovascular invasion (present vs absent) | 3.6 | 0.91–13.9 | 0.068 | 16.9 | 1.4–203 | 0.026 |
| Necrosis (present vs absent) | 3.3 | 1.04–10.8 | 0.043 | 2.7 | 0.4–19 | 0.33 |
| NTRK fusion (NTRK3 vs NTRK1/2) | 2.2 | 0.68–7.1 | 0.19 | 1.6 | 0.2–12 | 0.65 |
| Multivariable | DFS | OS | ||||
| HR | CI (95%) | p | HR | CI (95%) | p | |
| Mitoses/10 HPFs | 1.07 | 1.02–1.13 | 0.008 | 1.13 | 0.997–1.28 | 0.055 |
| Lymphovascular invasion (present vs absent) | 3.3 | 0.8–14 | 0.11 | 51 | 1.3–2041 | 0.036 |
| Necrosis (present vs absent) | 3.7 | 1.03–13.3 | 0.045 | 6.1 | 0.4–88 | 0.19 |
*
No stage 1A patients died from disease, precluding calculation of HR.